Was ist Spermidin und wie beeinflusst es die Gesundheit?

What is spermidine and how does it affect health?

Apr 27, 2023Robert Barabas-Steiner

What is spermidine?

Spermidine is a naturally occurring substance that occurs in all living organisms and was first discovered in the semen of mammals by Antoine van Leeuwenhoek in 1678. This gave rise to the bizarre name that has stuck to this day.

Our body has the ability to produce spermidine naturally, but as we age, production in the body slows down and spermidine levels begin to decline. Spermidine is also found in various foods such as wheat germ, soybeans, mushrooms, legumes and in fermented foods.

One of the best-known effects of spermidine is its ability to promote the autophagy process in the body. Autophagy is a natural process in which the body recycles damaged cells and reuses the cellular components to form new, healthy cells. This is important for maintaining the health of tissues and organs and slowing down the aging process. Autophagy can also be triggered by (intermittent) fasting, here the 16:8 rule applies: 16 hours of fasting, 8 hours of eating.

In 2020, scientists at the Charité in Berlin discovered that the coronavirus slows down the autophagy process so that it can multiply. The cell's metabolism is changed, causing spermidine levels to drop sharply. By administering spermidine, virus replication in infected cell cultures was reduced by around 85%. Previous work by Prof. Katharina Simon from Oxford has already shown that spermidine strengthens immune function, especially the antiviral immune response of T cells. This means that spermidine could have a double effect against coronaviruses, by inhibiting replication and by strengthening immune cells.

In addition, spermidine can improve cognitive function and reduce the risk of neurodegenerative diseases such as Alzheimer's and Parkinson's. According to a study by the University of Applied Sciences Wiener Neustadt in 2020, there is a significant connection between the spermidine concentration in the blood and memory performance. An increase in spermidine levels was observable after just one month of spermidine administration and significantly improved memory performance was observed after just 3 months.

Spermidine may also improve cardiovascular health by lowering blood pressure and reducing inflammation. A 2017 study in the Journal of the American Heart Association found that higher spermidine intake was associated with a reduced risk of heart disease.

Further clinical studies are needed to make clear statements, but spermidine is one of the greatest hopes in longevity and anti-aging research.

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